Lapatinib ditosylate

CAS No. 388082-77-7

Lapatinib ditosylate ( GW 572016 ditosylate;GW-572016 ditosylate )

Catalog No. M14335 CAS No. 388082-77-7

A reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 35 Get Quote
50MG 48 Get Quote
100MG 60 Get Quote
200MG 78 Get Quote
500MG 117 Get Quote
1G 135 Get Quote

Biological Information

  • Product Name
    Lapatinib ditosylate
  • Note
    Research use only, not for human use.
  • Brief Description
    A reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.
  • Description
    A reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively; displays no significant activity against other kinases, including ErbB4, c-Src, and c-Raf1; reduces tyrosine phosphorylation of EGFR and erbB2, and inhibits activation of Erk1/2 and AKT both in vitro and in vivo; inhibits tumor xenograft growth of the HN5 and BT474 cells in a dose-responsive manner at 30 and 100 mg/kg; orally active.Breast Cancer Approved
  • Synonyms
    GW 572016 ditosylate;GW-572016 ditosylate
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    C-Raf-1;c-Src;EGFR;HER2/ErbB2;ErbB2
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    388082-77-7
  • Formula Weight
    925.46
  • Molecular Formula
    C43H42ClFN4O10S3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=CC=C(C=C1)S(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.CS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1
  • Chemical Name
    4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xia W, et al. Oncogene. 2002 Sep 12;21(41):6255-63.
2. Rusnak DW, et al. Mol Cancer Ther. 2001 Dec;1(2):85-94.
3. Konecny GE, et al. Cancer Res. 2006 Feb 1;66(3):1630-9.
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