Lapatinib ditosylate
CAS No. 388082-77-7
Lapatinib ditosylate ( GW 572016 ditosylate;GW-572016 ditosylate )
Catalog No. M14335 CAS No. 388082-77-7
A reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
25MG | 35 | Get Quote |
|
50MG | 48 | Get Quote |
|
100MG | 60 | Get Quote |
|
200MG | 78 | Get Quote |
|
500MG | 117 | Get Quote |
|
1G | 135 | Get Quote |
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Biological Information
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Product NameLapatinib ditosylate
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NoteResearch use only, not for human use.
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Brief DescriptionA reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.
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DescriptionA reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively; displays no significant activity against other kinases, including ErbB4, c-Src, and c-Raf1; reduces tyrosine phosphorylation of EGFR and erbB2, and inhibits activation of Erk1/2 and AKT both in vitro and in vivo; inhibits tumor xenograft growth of the HN5 and BT474 cells in a dose-responsive manner at 30 and 100 mg/kg; orally active.Breast Cancer Approved
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SynonymsGW 572016 ditosylate;GW-572016 ditosylate
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PathwayAngiogenesis
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TargetEGFR
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RecptorC-Raf-1;c-Src;EGFR;HER2/ErbB2;ErbB2
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number388082-77-7
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Formula Weight925.46
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Molecular FormulaC43H42ClFN4O10S3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC=C(C=C1)S(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.CS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1
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Chemical Name4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xia W, et al. Oncogene. 2002 Sep 12;21(41):6255-63.
2. Rusnak DW, et al. Mol Cancer Ther. 2001 Dec;1(2):85-94.
3. Konecny GE, et al. Cancer Res. 2006 Feb 1;66(3):1630-9.
2. Rusnak DW, et al. Mol Cancer Ther. 2001 Dec;1(2):85-94.
3. Konecny GE, et al. Cancer Res. 2006 Feb 1;66(3):1630-9.
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